Cases of SARS-CoV-2 are detected in tribal communities. Indigenous Americans experience among the highest rates of COVID-19 disease and death in the U.S. The Center pivots all available personnel to conduct testing and provide support for isolation and quarantine in tribal communities. As vaccines are developed, the Center obtains local approval to offer Navajo and White Mountain Apache community members the opportunity to participate in the Pfizer COVID-19 vaccine trial. The vaccine is proven to be highly effective and, following EUA, vaccine uptake is high amongst Indigenous Americans.